Primary acinic cell carcinoma of the breast journal of. Acinic cell carcinoma accc of breast was first described by roncaroli et al. Acinic cell carcinoma is a malignant tumor representing 2% of all salivary tumors. Localization between 81% and 98% of accs of the salivary glands occur in the parotid, 11% in the submandibular gland, and 3% to 12% in the minor salivary glands, most commonly in the palate. Primary acinic cell carcinoma of the breast associated with. Such neoplasms arising in minor salivary gland tissue are extremely rare, but may be found in all sites containing normal or.
Acinic cell carcinoma of the parotid gland with four. A case report primary acinic cell carcinoma acc of the lung is very rare and this tumor. Enhancer hijacking activates oncogenic transcription factor. Acinic cell carcinoma acc is a special type of breast carcinoma showing serous differentiation, with zymogentype cytoplasmic granules, similar to acinic cell carcinoma arising in the parotid gland eusebi et al. The majority arise in the parotid gland, most commonly in women. We report here on a case of primary acc of the lung. Malignant salivary gland tumors were seen in 16 cases. Acinic cell carcinoma salivary glands radiology reference. Acinic cell carcinoma is the fourth most common malignant parotid gland tumour after mucoepidermoid carcinoma mec, adenoid cystic carcinoma adcc and carcinoma ex pleomorphic adenoma. This cancer, commonly found in the salivary glands and pancreas may also be referred to using the names acinar cell carcinoma, acinic cell tumor, acinic cell adenocarcinoma, acinar cell adenocarcinoma, acinose carcinoma, and acinous carincoma. On the core biopsy, a diagnosis of acinic cell carcinoma was made, a rare diagnosis.
Acinic cell carcinoma is the second most common salivary gland malignancy, representing approximately 4% to 6% of all salivary gland neoplasms and up to 17% of malignancies. Histopathology of the salivary glands will be of interest not only to. Review and updates of immunohistochemistry in selected. Acinic cell carcinoma of the lung is a very rare variant of lung cancer that, in this organ, is classified among the salivary gland like carcinoma of the lung. Acinic cell carcinoma occurs in the parotid gland more often than primary planoepithelial carcino ma. This included 6 cases of mucoepidermoid carcinoma, 3 cases of adenoid cystic carcinoma, 2 cases of acinic cell carcinoma, one salivary duct carcinoma, one adenocarcinoma, one epithelial myoepithelial carcinoma and one case of rhabdomyosarcoma. Acinic cell carcinoma of the breast arising in microglandular. Despite it being known from the beginning of the 20th century nasse 1892, foote and frazell 1953 were the first to take into consideration the potentially malignant behaviour of. Fine needle aspiration cytology of salivary gland lesions. Acinic cell carcinoma of the parotid gland radiology. Metastasis of acinic cell carcinoma of the parotid gland. Acinic cell carcinoma, abbreviated accc, is a rare type of salivary gland cancer. An acinic cell carcinoma acc of salivary gland is a type of malignant epithelial tumor affecting either the major or minor salivary glands. I present with this, a case report where incidental results detected by histopathology examination with acinic cell carcinoma of the parotid gland which is a rare entity of parotid tumour.
Purpose acinic cell carcinoma accs is uncommon malignant epithelial neoplasm of the salivary glands. Mar 23, 2018 an acinic cell carcinoma acc of salivary gland is a type of malignant epithelial tumor affecting either the major or minor salivary glands. Clinical analysis of acinic cell carcinoma in parotid gland. Acinic cell carcinoma is a lowgrade malignant neoplasm that constitutes approximately 17% of sgts and mostly develops in the parotid gland 80%. Dec 12, 2014 acinic cell carcinoma arising in salivary glands is a rare tumor, accounting for 2% to 5% of the primary neoplasms of the parotid gland. Immunostaining of all salivary tumors is summarized in table 1. Immunoreactivity for ar was seen in 14 of 14 carcinoma ex pleomorphic adenomas, 6 of 6 salivary duct carcinomas, and 2 of 2 basal cell adenocarcinomas but in only 2. Another significant feature is the incorporation of important knowledge gained during the past few years regarding the genetics of salivary gland tumors. Apr 22, 2017 april 22, 2017 salivary duct carcinoma, salivary gland cancer, salivary gland cancer trial no comments 72m a closer look at her2 in salivary duct carcinoma sdc we have made some assumptions that since erbb2 gene amplifications occur frequently in salivary duct carcinoma sdc, they must be driving this cancer. The minor salivary glands consist of 800 small mucussecreting glands located throughout the lining of the oral cavity. Acinic cell carcinoma acc is an infrequent malignant salivary gland tumor, and most cases arise in the major glands, particularly the parotid. Enhancer hijacking activates oncogenic transcription. Herein, we report a case of acinic cell carcinoma of the breast in a 41year old female presenting with a palpable breast mass along with. It is observed in a wide age category of both children and adults.
Trk expression is not entirely sensitive or specific for secretory carcinoma, nuclear staining distinguishes secretory carcinoma from mimics. During courses the author has given, consultants and trainees alike have. Acinic cell carcinoma acc is a lowgrade malignant salivary neoplasm that constitutes approximately 17% of primary salivary gland malignancies. Immunoreactivity for ar was seen in 14 of 14 carcinoma ex pleomorphic adenomas, 6 of 6 salivary duct carcinomas, and 2 of 2 basal cell adenocarcinomas but in only 2 of 10 acinic cell carcinomas. Acinic cell carcinoma of minor salivary glands ferlito. Cell proliferation correlates with prognosis in acinic cell carcinomas of salivary gland origin. Acinic cell carcinoma acc is a lowgrade malignant neoplasm of the salivary gland that constitutes approximately 17% of all primary salivary gland malignancies, parotid gland being the most. Letter to the editor international journal of surgical. The disease presents as a slow growing mass, associated with pain or tenderness in 50% of the cases. This type of neoplasm is commonly found in the parotid gland and has a diffuse infiltrative growth pattern, with small acinar or glandular structures composed of a monotonous proliferation of cells with a granular or clear. Fewer than 1% of malignancies beginning in the lower respiratory tract are acinic cell carcinomas. The salivary glands are classified as major or minor.
Jan 21, 2019 acinic cell carcinoma acicc is a rare salivary gland carcinoma that is poorly understood. Primary acinic cell carcinoma of the breast associated with an intraductal acinic cell component 4. Such neoplasms arising in minor salivary gland tissue are extremely rare, but may be found in all sites containing normal or aberrant salivary. Mar 10, 2016 acinic cell carcinoma is the fourth most common malignant parotid gland tumour after mucoepidermoid carcinoma mec, adenoid cystic carcinoma adcc and carcinoma ex pleomorphic adenoma. Clear cells in acinic cell carcinoma of the salivary gland are thought to be caused by tissue processing artefact or changes in organelles, including dilated rough endoplasmic reticulum. Damiani s, pasquinelli g, lamovec j, peterse jl, eusebi v. Acinic cell carcinoma arising in salivary glands is a rare tumor, accounting for 2% to 5% of the primary neoplasms of the parotid gland. This type of neoplasm is commonly found in the parotid gland and has a diffuse infiltrative growth pattern, with small acinar or glandular structures composed of a monotonous proliferation of cells with a granular or clear cytoplasm. It is characterized by a low and highgrade component juxtaposed with one another and tends to take on a more aggressive clinical course than its lowgrade counterpart, suggesting a poor clinical outcome. It is also known as acinic cell adenocarcinoma it should not to be confused with pancreatic acinar cell carcinoma. Monotonous proliferation of cells with abundant finely granular, weakly eosinophilic or clear vacuolated cytoplasm, central round nuclei and prominent nucleoli, resembling acinic cells of salivary gland j clin pathol 2003. Acinic cell carcinomas of the salivary glands are rare malignant neoplasms that account for % of all salivary gland tumors. Primary acinic cell carcinoma of the breast is a rare variant of breast carcinoma that has been suggested to carry a good prognosis this paper describes a case of primary acinic cell carcinoma of the breast following chemotherapy, which had an unfavourable prognosis, demonstrating that this lesion can be associated with a poor prognosis.
In the head and neck region, the parotid gland is the predominant site of origin and women are usually more frequently diagnosed than men. Acinic cell carcinoma accc of the breast is a rare histological type of malignant epithelial neoplasm exhibiting acinic cell differentiation. A mapping of the immunophenotypes of salivary gland tumors is neither available today and will greatly benefit in routine diagnostic work. A retrospective clinicopathologic study of 12 cases. The major salivary glands consist of the parotid, submandibular, and sublingual glands. Management of metastatic acc is challenging due to limited data in the literature. Acinic cell carcinoma of minor salivary gland origin the. Highgrade transformation dedifferentiation of acinic cell. Immunohistochemical study of 30 cases using the mib 1 antibody in formalinfixed paraffin.
Mar 30, 2012 dog1 expression in acinar and ductal tumors. Acinic cell carcinoma is a rare breast tumour belonging to salivary glandlike tumours of the breast. Another important feature to incorporate is the newly gained knowledge about genetics in salivary gland tumors, a knowledge that has emerged during the last 34 years only and is growing continuously. Over the last 25 years it has become more and more evident that salivary gland pathology is by far the subject within head and neck pathology that causes most diagnostic challenges and problems for general pathologists. Drut gland with massive deposits of globular amyloid. Highgrade transformation dedifferentiation of acinic. Acinic cell carcinoma acicc is a rare salivary gland carcinoma that is poorly understood. Sep 27, 2018 acinic cell carcinoma acc of the breast is extremely rare subtype of triplenegative breast carcinoma and demonstrates extensive morphologic overlap with acinic cell carcinoma of the salivary gland. Relapsed acinic cell carcinoma of the parotid gland with. Acinic cell carcinoma is a rare breast tumour belonging to salivary gland like tumours of the breast. Selected salivary gland and head and neck tumors acinic cell carcinoma acinic cell carcinoma demonstrates both serous acinar and intercalated ductal epithelial differentiation. Primary acinic cell carcinoma of the breast associated. April 22, 2017 salivary duct carcinoma, salivary gland cancer, salivary gland cancer trial no comments 72m a closer look at her2 in salivary duct carcinoma sdc we have made some assumptions that since erbb2 gene amplifications occur frequently in salivary duct carcinoma sdc, they must be driving this cancer.
Papillary cystic acinic cell carcinoma with many psammoma bodies, so called psammoma bodyrich papillary cystic acinic cell. Acinic cell carcinoma with highgrade transformation of the salivary gland is an unusual variant with less than fifty cases being reported in the literature. When these tumors are welldifferentiated, the neoplasia has innocuous aspect, due to the similarity to normal parotid tissue. Interestingly, acicc was originally described as an adenoma, but from the 1950s the term acinic cell adenocarcinoma was coined when its ability to metastasize and recur locally had been recognized 3, 4. Histopathology of the salivary glands springerlink. Acinic cell carcinoma an overview sciencedirect topics. Three cases of acinic cell carcinoma of minor salivary glands, located respectively in the larynx, base of the tongue, and right tonsil, were encountered at the section of pathology of the ent department of the university of padua between 1974 and 1978. Acinic cell carcinoma is an uncommon lowgrade malignant tumor of the salivary glands, in which some cells resemble normal acinic cells. A case report primary acinic cell carcinoma acc of the lung is very rare and this tumor is thought to arise from pluripotent cells of the submucosal glands of the tracheobronchial tree. I present with this, a case report where incidental results detected by histopathology examination with acinic cell carcinoma of the parotid gland which is a. Initially the malignancy of this tumor was uncertain. Three cases of acinic cell carcinoma of minor salivary glands, located respectively in the larynx, base of the tongue, and right tonsil, were encountered at the section of pathology of the ent depa.
Acinic cell carcinoma acc is a lowgrade malignant neoplasm of the salivary gland that constitutes approximately 17% of all primary salivary gland malignancies, parotid gland being the. Introduction acinic cell carcinoma acc is one of the rarely occurring malignant salivary gland tumours. Name l define l risk l detect l treatment l stagegrade l followup l metsrecur l link. Over the past 25 years it has become more and more evident that salivary gland pathology is by far the subject within head and neck pathology that causes the most diagnostic challenges and problems fo. Acinic cell carcinoma acicc is a relatively uncommon malignancy accounting for 1 to 6% of all salivary gland tumors and 15% of all malignant tumors in parotid gland 1, 2. The most common malignant major and minor salivary gland tumor is the mucoepidermoid carcinoma, which comprises about 10% of all salivary gland neoplasms and approximately 35% of malignant salivary gland neoplasms. Acinic cell carcinoma of the parotid gland with four morphological features. Metastasis of acinic cell carcinoma of the parotid gland to. Basic salivary gland pathology 1 basic salivary gland pathology jennifer l. According to the world health organization, acinic cell carcinoma acc is a malignant epithelial neoplasm of the salivary glands in which at least some of the neoplastic cells demonstrate serous acinar cell differentiation characterized by cytoplasmic zymogen secretory granules. Acinic cell carcinoma of the parotid gland radiology case. Pathology pathology may superficially resemble normal serous acinar cells of the salivary glands. Here the authors perform genomic, transcriptomic and epigenomic profiling of acicc and find highly.
Salivary gland tumours or neoplasms are tumours that form in the tissues of salivary glands. Case report primary acinic cell carcinoma of the breast. An approach to the why is salivary gland pathology. It is one of several rare subtypes of breast carcinoma that demonstrate morphologic overlap with the repertoire of tumors seen. Wt, oncocytic cystadenoma, and acinic cell carcinoma. All 28 acinic cell carcinomas showed dog1 staining, and 93% 2628 tumors showed. Primary acc of the lung is a rare neoplasm that makes up. Seventeen percent arise in the intraoral minor salivary glands buccal mucosa, upper lip. Besides the parotid gland the tumour can be seen in the submandibular gland, lacrimal glands and minor salivary glands of the oral cavity, throat and larynx 3.
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